( S )-Crizotinib

• Supplier: Tocris Bioscience
• Catalog: 4368
• Prices: $145.00, $609.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1374356-45-2
• Chemical Name: 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
• Formula: C21H22Cl2FN5O
• Molecular Weight: 450.34
• Purity: >98 %
• Description: Potent MTH1 inhibitor (IC 50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro . Suppresses tumor growth ~50% in a colon cancer carcinoma xenograft model.

Product References

The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ - The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+

Escande D, Thuringer D, Leguern S, Cavero I. Biochem Biophys Res Commun. 1988 Jul 29;154(2):620-5.

Cromakalim, a potassium channel activator: a comparison of its cardiovascular - Cromakalim, a potassium channel activator: a comparison of its cardiovascular

Longman SD, Clapham JC, Wilson C, Hamilton TC. J Cardiovasc Pharmacol. 1988;12(5):535-42.

Comparative effects of K+ channel blockade on the vasorelaxant activity of - Comparative effects of K+ channel blockade on the vasorelaxant activity of

Wilson C, Coldwell MC, Howlett DR, Cooper SM, Hamilton TC. Eur J Pharmacol. 1988 Aug 2;152(3):331-9.