CRSP-1

• Supplier: Tocris Bioscience
• Catalog: 1377
• Prices: $219.00
• Sizes: 100 µg
• Function Type: Agonist
• Cas Number: 697327-12-1
• Formula: C175H294N54O49S5
• Molecular Weight: 4098.88
• Description: Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED 50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin receptors. Inhibits formation of multinuclear osteoclasts with similar efficacy to CT in vitro . Suppresses food intake and increases body temperature in free-feeding rats, and significantly decreases plasma calcium levels in vivo .

Product References

Calcitonin receptor-stimulating peptide, a new member of the calcitonin - Calcitonin receptor-stimulating peptide, a new member of the calcitonin

Katafuchi T, Kikumoto K, Hamano K, Kangawa K, Matsuo H, Minamino N. J Biol Chem. 2003 Apr 4;278(14):12046-54. Epub 2003 Jan 29.

Central effects of calcitonin receptor-stimulating peptide-1 on energy - Central effects of calcitonin receptor-stimulating peptide-1 on energy

Sawada H, Yamaguchi H, Shimbara T, Toshinai K, Mondal MS, Date Y, Murakami N, Katafuchi T, Minamino N, Nunoi H, Nakazato M. Endocrinology. 2006 Apr;147(4):2043-50. Epub 2006 Jan 12.

A novel member of the calcitonin gene-related peptide family, calcitonin - A novel member of the calcitonin gene-related peptide family, calcitonin

Notoya M, Arai R, Katafuchi T, Minamino N, Hagiwara H. Eur J Pharmacol. 2007 Apr 10;560(2-3):234-9. Epub 2007 Feb 1.