CS 2100

• Supplier: Tocris Bioscience
• Catalog: 3713
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 913827-99-3
• Chemical Name: 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylicacid
• Formula: C25H23N3O4S
• Molecular Weight: 461.53
• Purity: >97 %
• Description: Sphingosine-1-phosphate receptor 1 (S1P 1 ) agonist (EC 50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P 1 over S1P 3 . Displays efficacy in a rat adjuvant-induced arthritis model.

Product References

Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing - Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing

Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Nara F, Kawase Y, Yabe Y, Nakai D, Kamiyama E, Urasaki-Kaneno Y, Shimozato T, Doi-Komuro H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Nishi T. Eur J Med Chem. 2012 May;51:92-8.

Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. - Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.

Nakamura T, Asano M, Sekiguchi Y, Mizuno Y, Tamaki K, Kimura T, Nara F, Kawase Y, Shimozato T, Doi H, Kagari T, Tomisato W, Inoue R, Nagasaki M, Yuita H, Oguchi-Oshima K, Kaneko R, Watanabe N, Abe Y, Nishi T. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1788-92.