CTOP

Name CTOP
Supplier Tocris Bioscience
Catalog 5130
Prices $175.00
Sizes 1 mg
Function Type Antagonist
Cas Number 103429-31-8
Formula C50H67N11O11S2
Molecular Weight 1062.28
Description Potent and selective μ opioid receptor antagonist (K i values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo . Also increases K + currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.
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Product References

Central effects of the potent and highly selective mu opioid antagonist - Central effects of the potent and highly selective mu opioid antagonist

Gulya K, Krivan M, Nyolczas N, Sarnyai Z, Kovacs GL. Eur J Pharmacol. 1988 Jun 10;150(3):355-60.

[3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly - [3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly

Hawkins KN, Knapp RJ, Lui GK, Gulya K, Kazmierski W, Wan YP, Pelton JT, Hruby VJ, Yamamura HI. J Pharmacol Exp Ther. 1989 Jan;248(1):73-80.

Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity. - Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity.

Badiani A, Leone P, Stewart J. Brain Res. 1995 Aug 28;690(1):112-6.

The mu-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) - The mu-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP)

Chieng B, Connor M, Christie MJ. Mol Pharmacol. 1996 Sep;50(3):650-5.