Cucurbitacin I

• Supplier: Tocris Bioscience
• Catalog: 4883
• Prices: $225.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 2222-07-3
• Chemical Name: (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
• Formula: C30H42O7
• Molecular Weight: 514.65
• Purity: >98 %
• Description: Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Product References

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer - Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer

Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Cancer Res. 2003 Mar 15;63(6):1270-9.

Regulation of dendritic cell differentiation and antitumor immune response in - Regulation of dendritic cell differentiation and antitumor immune response in

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Role of signal transducer and activator of transcription-3 in estradiol-mediated - Role of signal transducer and activator of transcription-3 in estradiol-mediated

Dziennis S, Jia T, Ronnekleiv OK, Hurn PD, Alkayed NJ. J Neurosci. 2007 Jul 4;27(27):7268-74.