CY 208-243

Name CY 208-243
Supplier Tocris Bioscience
Catalog 5149
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 100999-26-6
Chemical Name (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
Formula C19H18N2
Molecular Weight 274.36
Description Centrally active dopamine D 1 receptor agonist, selective over D 2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC 50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.
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Product References

Antiparkinsonian activity of CY 208-243, a partial D-1 dopamine receptor agonist, - Antiparkinsonian activity of CY 208-243, a partial D-1 dopamine receptor agonist,

Temlett JA, Quinn NP, Jenner PG, Marsden CD, Pourcher E, Bonnet AM, Agid Y, Markstein R, Lataste X. Mov Disord. 1989;4(3):261-5.

Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. - Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy.

Andersen PH, Jansen JA. Eur J Pharmacol. 1990 Jun 12;188(6):335-47.