Cycloheximide

• Supplier: Tocris Bioscience
• Catalog: 3999
• Prices: $75.00
• Sizes: 100 mg
• Function Type: Inhibitor
• Cas Number: 66-81-9
• Chemical Name: 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
• Formula: C15H23NO4
• Molecular Weight: 281.35
• Purity: >97 %
• Description: Selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (K i = 3.4 μ M). Antifungal antibiotic.

Product References

The mechanism by which cycloheximide and related glutarimide antibiotics inhibit - The mechanism by which cycloheximide and related glutarimide antibiotics inhibit

Obrig TG, Culp WJ, McKeehan WL, Hardesty B. J Biol Chem. 1971 Jan 10;246(1):174-81.

Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential - Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential

Christner C, Wyrwa R, Marsch S, Kullertz G, Thiericke R, Grabley S, Schumann D, Fischer G. J Med Chem. 1999 Sep 9;42(18):3615-22.

Cycloheximide-induced T-cell death is mediated by a Fas-associated death - Cycloheximide-induced T-cell death is mediated by a Fas-associated death

Tang D, Lahti JM, Grenet J, Kidd VJ. J Biol Chem. 1999 Mar 12;274(11):7245-52.