Cyclopamine

• Supplier: Tocris Bioscience
• Catalog: 0970
• Prices: $185.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 4449-51-8
• Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
• Formula: C27H41NO2
• Molecular Weight: 411.63
• Purity: >97 %
• Description: Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo . Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Product References

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. - Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Chen JK, Taipale J, Cooper MK, Beachy PA. Genes Dev. 2002 Nov 1;16(21):2743-8.

Cancer: a twist in a hedgehog's tale. - Cancer: a twist in a hedgehog's tale.

Scott MP. Nature. 2003 Oct 23;425(6960):780-2.

Production of pancreatic hormone-expressing endocrine cells from human embryonic - Production of pancreatic hormone-expressing endocrine cells from human embryonic

D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE. Nat Biotechnol. 2006 Nov;24(11):1392-401. Epub 2006 Oct 19.

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells - Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells

Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, Matsui W, Piccirillo S, Vescovi AL, DiMeco F, Olivi A, Eberhart CG. Stem Cells. 2007 Oct;25(10):2524-33. Epub 2007 Jul 12.