Cyclosporin A

• Supplier: Tocris Bioscience
• Catalog: 3493
• Prices: $115.00
• Sizes: 100 mg
• Cas Number: 59865-13-3
• Formula: C62H111N11O12
• Molecular Weight: 1202.63
• Purity: >99 %
• Description: Immunosuppressant; inhibits phosphatase activity of calcineurin (IC 50 = 5 nM). Also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).

Product References

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and - Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and

Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3686-90.

Inhibition of the mitochondrial permeability transition by cyclosporin A during - Inhibition of the mitochondrial permeability transition by cyclosporin A during

Broekemeier KM, Pfeiffer DR. Biochemistry. 1995 Dec 19;34(50):16440-9.

Evidence that cyclosporin A and dexamethasone inhibit allergic airway - Evidence that cyclosporin A and dexamethasone inhibit allergic airway

Nakata A, Kaminuma O, Mori A, Ogawa K, Kikkawa H, Naito K, Ikezawa K, Suko M, Okudaira H. Br J Pharmacol. 1998 Aug;124(7):1425-32.

Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem - Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem

Yan P, Nagasawa A, Uosaki H, Sugimoto A, Yamamizu K, Teranishi M, Matsuda H, Matsuoka S, Ikeda T, Komeda M, Sakata R, Yamashita JK. Biochem Biophys Res Commun. 2009 Jan 30;379(1):115-20. doi: