Cyclothiazide

• Supplier: Tocris Bioscience
• Catalog: 1101
• Prices: $79.00, $335.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 2259-96-3
• Chemical Name: 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide
• Formula: C14H16ClN3O4S2
• Molecular Weight: 389.87
• Purity: >98 %
• Description: Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits. Also available as part of the AMPA Receptor Tocriset™ .

Product References

Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole - Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole

Desai MA, Burnett JP, Ornstein PL, Schoepp DD. J Pharmacol Exp Ther. 1995 Jan;272(1):38-43.

Allosteric regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate - Allosteric regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate

Donevan SD, Rogawski MA. Neuroscience. 1998 Dec;87(3):615-29.

The norbornenyl moiety of cyclothiazide determines the preference for flip-flop - The norbornenyl moiety of cyclothiazide determines the preference for flip-flop

Kessler M, Rogers G, Arai A. Neurosci Lett. 2000 Jun 23;287(2):161-5.