CYM 50358 hydrochloride

Name CYM 50358 hydrochloride
Supplier Tocris Bioscience
Catalog 4678
Prices $209.00, $879.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Chemical Name N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamidehydrochloride
Formula C20H18Cl2N2O2.HCl
Molecular Weight 425.74
Purity >98 %
Description Potent S1P 4 antagonist (IC 50 = 25 nM). Displays selectivity for S1P 4 against S1P 1 , S1P 2 , S1P 3 and S1P 5 receptors.
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Product References

Discovery, design and synthesis of the first reported potent and selective - Discovery, design and synthesis of the first reported potent and selective

Guerrero M, Urbano M, Velaparthi S, Zhao J, Schaeffer MT, Brown S, Rosen H, Roberts E. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6.

TGFbeta1 evokes myoblast apoptotic response via a novel signaling pathway - TGFbeta1 evokes myoblast apoptotic response via a novel signaling pathway

Cencetti F, Bernacchioni C, Tonelli F, Roberts E, Donati C, Bruni P. FASEB J. 2013 Nov;27(11):4532-46.