Cystamine dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0996
• Prices: $49.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 56-17-7
• Chemical Name: 2,2'-Diaminodiethyldisulfidedihydrochloride
• Formula: C4H12N2S2.2HCl
• Molecular Weight: 225.2
• Description: Transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.

Product References

Therapeutic effects of cystamine in a murine model of Huntington's disease. - Therapeutic effects of cystamine in a murine model of Huntington's disease.

Dedeoglu A, Kubilus JK, Jeitner TM, Matson SA, Bogdanov M, Kowall NW, Matson WR, Cooper AJ, Ratan RR, Beal MF, Hersch SM, Ferrante RJ. J Neurosci. 2002 Oct 15;22(20):8942-50.

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via - Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via

Borrell-Pages M, Canals JM, Cordelieres FP, Parker JA, Pineda JR, Grange G, Bryson EA, Guillermier M, Hirsch E, Hantraye P, Cheetham ME, Neri C, Alberch J, Brouillet E, Saudou F, Humbert S. J Clin Invest. 2006 May;116(5):1410-24. Epub 2006 Apr 6.

Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of - Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of

Mao Z, Choo YS, Lesort M. Eur J Neurosci. 2006 Apr;23(7):1701-10.