CZC 25146

• Supplier: Tocris Bioscience
• Catalog: 4674
• Prices: $205.00, $865.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1191911-26-8
• Chemical Name: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
• Formula: C22H25FN6O4S
• Molecular Weight: 488.54
• Purity: >98 %
• Description: Potent LRRK2 inhibitor (IC 50 values are 4.76 and 6.87 nM for for wild-type and G2019S mutant forms of LRRK2, respectively). Also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. Attenuates mutant LRRK2-induced injury of cultured rodent and human neurons. Cell permeable.

Product References

Chemoproteomics-based design of potent LRRK2-selective lead compounds that - Chemoproteomics-based design of potent LRRK2-selective lead compounds that

Ramsden N, Perrin J, Ren Z, Lee BD, Zinn N, Dawson VL, Tam D, Bova M, Lang M, Drewes G, Bantscheff M, Bard F, Dawson TM, Hopf C. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's - Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's

Kramer T, Lo Monte F, Goring S, Okala Amombo GM, Schmidt B. ACS Chem Neurosci. 2012 Mar 21;3(3):151-60.