D 4476

• Supplier: Tocris Bioscience
• Catalog: 2334
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 301836-43-1
• Chemical Name: 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
• Formula: C23H18N4O3
• Molecular Weight: 398.41
• Purity: >99 %
• Description: Selective inhibitor of casein kinase 1 (CK1) and TGF- β type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.

Product References

Identification of novel inhibitors of the transforming growth factor beta1 - Identification of novel inhibitors of the transforming growth factor beta1

Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A, Olson BA, Weinstock J, Laping NJ. J Med Chem. 2002 Feb 28;45(5):999-1001.

D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific - D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific

Rena G, Bain J, Elliott M, Cohen P. EMBO Rep. 2004 Jan;5(1):60-5.

The selectivity of protein kinase inhibitors: a further update. - The selectivity of protein kinase inhibitors: a further update.

Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. Biochem J. 2007 Dec 15;408(3):297-315.