D609

• Supplier: Tocris Bioscience
• Catalog: 2902
• Prices: $129.00, $499.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 83373-60-8
• Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5-yl)carbonopotassiumdithioate
• Formula: C11H15OS2K
• Molecular Weight: 266.46
• Purity: >98 %
• Description: Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .

Product References

Induction of nitric oxide synthase activity in phagocytic cells inhibited by - Induction of nitric oxide synthase activity in phagocytic cells inhibited by

Tschaikowsky K, Meisner M, Schonhuber F, Rugheimer E. Br J Pharmacol. 1994 Nov;113(3):664-8.

The antiviral, antitumoural xanthate D609 is a competitive inhibitor of - The antiviral, antitumoural xanthate D609 is a competitive inhibitor of

Amtmann E. Drugs Exp Clin Res. 1996;22(6):287-94.

Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve - Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve

Li Y, Maher P, Schubert D. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7748-53.

D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent - D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent

Zhou D, Lauderback CM, Yu T, Brown SA, Butterfield DA, Thompson JS. J Pharmacol Exp Ther. 2001 Jul;298(1):103-9.