D-64131

• Supplier: Tocris Bioscience
• Catalog: 1437
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 74588-78-6
• Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone
• Formula: C16H13NO2
• Molecular Weight: 251.28
• Purity: >99 %
• Description: Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC 50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo .

Product References

Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, - Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory,

Mahboobi S, Pongratz H, Hufsky H, Hockemeyer J, Frieser M, Lyssenko A, Paper DH, Burgermeister J, Bohmer FD, Fiebig HH, Burger AM, Baasner S, Beckers T. J Med Chem. 2001 Dec 20;44(26):4535-53.

2-aroylindoles, a novel class of potent, orally active small molecule tubulin - 2-aroylindoles, a novel class of potent, orally active small molecule tubulin

Beckers T, Reissmann T, Schmidt M, Burger AM, Fiebig HH, Vanhoefer U, Pongratz H, Hufsky H, Hockemeyer J, Frieser M, Mahboobi S. Cancer Res. 2002 Jun 1;62(11):3113-9.