Daminozide

• Supplier: Tocris Bioscience
• Catalog: 1171
• Prices: $59.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 1596-84-5
• Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioicacid
• Formula: C6H12N2O3
• Molecular Weight: 160.17
• Description: Histone demethylase KDM2/7 subfamily inhibitor (IC 50 values are 0.55, 1.5 and 2.1 μ M for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC 50 > 100 μ M).

Product References

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 - Plant growth regulator daminozide is a selective inhibitor of human KDM2/7

Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A. J Med Chem. 2012 Jul 26;55(14):6639-43.