Name | Damnacanthal |
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Supplier | Tocris Bioscience |
Catalog | 4684 |
Prices | $165.00 |
Sizes | 1 mg |
Function Type | Inhibitor |
Cas Number | 477-84-9 |
Chemical Name | 9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde |
Formula | C16H10O5 |
Molecular Weight | 282.25 |
Purity | >98 % |
Description | Potent inhibitor of p56 lck tyrosine kinase activity (IC 50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59 fyn and p60 src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca 2+ in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro . |
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Hiramatsu T, Imoto M, Koyano T, Umezawa K. Cancer Lett. 1993 Sep 30;73(2-3):161-6.
Faltynek CR, Schroeder J, Mauvais P, Miller D, Wang S, Murphy D, Lehr R, Kelley M, Maycock A, Michne W, et al.. Biochemistry. 1995 Sep 26;34(38):12404-10.
Aoki K, Parent A, Zhang J. Eur J Pharmacol. 2000 Jan 10;387(2):119-24.