Damnacanthal

Name Damnacanthal
Supplier Tocris Bioscience
Catalog 4684
Prices $165.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 477-84-9
Chemical Name 9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde
Formula C16H10O5
Molecular Weight 282.25
Purity >98 %
Description Potent inhibitor of p56 lck tyrosine kinase activity (IC 50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59 fyn and p60 src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca 2+ in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro .
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