Dantrolene, sodium salt

Name Dantrolene, sodium salt
Supplier Tocris Bioscience
Catalog 5122
Prices $75.00
Sizes 100 mg
Cas Number 14663-23-1
Chemical Name 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedionesodiumsalt
Formula C14H9N4NaO5
Molecular Weight 336.23
Purity >98 %
Description Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
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Product References

Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves - Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves

Hotchkiss RS, Karl IE. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3039-43.

Dantrolene inhibits long-term depression and depotentiation of synaptic - Dantrolene inhibits long-term depression and depotentiation of synaptic

O'Mara SM, Rowan MJ, Anwyl R. Neuroscience. 1995 Oct;68(3):621-4.

Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular - Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular

Zhao F, Li P, Chen SR, Louis CF, Fruen BR. J Biol Chem. 2001 Apr 27;276(17):13810-6. Epub 2001 Feb 5.