DAPTA

• Supplier: Tocris Bioscience
• Catalog: 2634
• Prices: $95.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 106362-34-9
• Formula: C35H56N10O15
• Molecular Weight: 856.89
• Description: Chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.

Product References

Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 - Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5

Ruff MR, Polianova M, Yang QE, Leoung GS, Ruscetti FW, Pert CB. Curr HIV Res. 2003 Jan;1(1):51-67.

Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T - Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T

Polianova MT, Ruscetti FW, Pert CB, Ruff MR. Antiviral Res. 2005 Aug;67(2):83-92.

Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and - Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and

Rosi S, Pert CB, Ruff MR, McGann-Gramling K, Wenk GL. Neuroscience. 2005;134(2):671-6.