Daptomycin

• Supplier: Tocris Bioscience
• Catalog: 2423
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Cas Number: 103060-53-3
• Chemical Name: N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone
• Formula: C72H101N17O26
• Molecular Weight: 1620.67
• Purity: >95 %
• Description: Lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo , including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.

Product References

Development of daptomycin for gram-positive infections. - Development of daptomycin for gram-positive infections.

Tally FP, DeBruin MF. J Antimicrob Chemother. 2000 Oct;46(4):523-6.

Structural transitions as determinants of the action of the calcium-dependent - Structural transitions as determinants of the action of the calcium-dependent

Jung D, Rozek A, Okon M, Hancock RE. Chem Biol. 2004 Jul;11(7):949-57.

Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive - Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive

Steenbergen JN, Alder J, Thorne GM, Tally FP. J Antimicrob Chemother. 2005 Mar;55(3):283-8. Epub 2005 Feb 10.

Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. - Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery.

Robbel L, Marahiel MA. J Biol Chem. 2010 Sep 3;285(36):27501-8.