DAU 5884 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3917
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 131780-48-8
• Chemical Name: 8-Methyl-8-azabicyclo-3-endo[3.2.1]oct-3-yl-1,4-dihydro-2-oxo-3(2H)-quinazolinecarboxylicacidesterhydrochloride
• Formula: C17H21N3O3.HCl
• Molecular Weight: 351.83
• Purity: >99 %
• Description: Selective muscarinic M 3 receptor antagonist. In bovine tracheal smooth muscle, inhibits methacholine-dependent effects on cell proliferation and muscle contractility.

Product References

Characterization of muscarinic receptors in guinea-pig uterus. - Characterization of muscarinic receptors in guinea-pig uterus.

Doods HN, Willim KD, Boddeke HW, Entzeroth M. Eur J Pharmacol. 1993 Dec 7;250(2):223-30.

Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic - Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic

Roffel AF, Elzinga CR, Zaagsma J. Eur J Pharmacol. 1993 Dec 7;250(2):267-79.

Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway - Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway

Gosens R, Nelemans SA, Grootte Bromhaar MM, McKay S, Zaagsma J, Meurs H. Am J Respir Cell Mol Biol. 2003 Feb;28(2):257-62.

Muscarinic M(3) receptor-dependent regulation of airway smooth muscle contractile - Muscarinic M(3) receptor-dependent regulation of airway smooth muscle contractile

Gosens R, Bromhaar MM, Tonkes A, Schaafsma D, Zaagsma J, Nelemans SA, Meurs H. Br J Pharmacol. 2004 Mar;141(6):943-50. Epub 2004 Mar 1.