| Name | DBeQ |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1467 |
| Prices | $159.00, $665.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 177355-84-9 |
| Chemical Name | N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine |
| Formula | C22H20N4 |
| Molecular Weight | 340.42 |
| Purity | >99 % |
| Description | Selective and reversible inhibitor of p97 ATPase (IC 50 = 1.5 μ M). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II. |
| Supplier Page | Shop |
Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. doi:
Chou TF, Deshaies RJ. Autophagy. 2011 Sep;7(9):1091-2. Epub 2011 Sep 1.