DBZ

• Supplier: Tocris Bioscience
• Catalog: 5095
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 209984-56-5
• Chemical Name: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
• Formula: C26H23F2N3O3
• Molecular Weight: 463.48
• Purity: >98 %
• Description: Inhibitor of γ -secretase. Blocks Notch cleavage (IC 50 < 2 nM) in a cell-based assay; inhibits the Notch pathway. Stimulates the formation of human iPSCs from human keratinocytes.

Product References

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts - Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts

van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H. Nature. 2005 Jun 16;435(7044):959-63.

Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect - Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect

Groth C, Alvord WG, Quinones OA, Fortini ME. Mol Pharmacol. 2010 Apr;77(4):567-74.

Notch inhibition allows oncogene-independent generation of iPS cells. - Notch inhibition allows oncogene-independent generation of iPS cells.

Ichida JK, TCW J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. Nat Chem Biol. 2014 Aug;10(8):632-9.