DC 260126

• Supplier: Tocris Bioscience
• Catalog: 4489
• Prices: $79.00, $335.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 346692-04-4
• Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
• Formula: C16H18FNO2S
• Molecular Weight: 307.38
• Purity: >98 %
• Description: Free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca 2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro . Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic ( db/db ) rats.

Product References

A novel class of antagonists for the FFAs receptor GPR40. - A novel class of antagonists for the FFAs receptor GPR40.

Hu H, He LY, Gong Z, Li N, Lu YN, Zhai QW, Liu H, Jiang HL, Zhu WL, Wang HY. Biochem Biophys Res Commun. 2009 Dec 18;390(3):557-63. doi:

DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but - DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but

Zhang X, Yan G, Li Y, Zhu W, Wang H. Biomed Pharmacother. 2010 Nov;64(9):647-51.

DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic - DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic

Sun P, Wang T, Zhou Y, Liu H, Jiang H, Zhu W, Wang H. PLoS One. 2013 Jun 11;8(6):e66744.