DCA

• Supplier: Tocris Bioscience
• Catalog: 5357
• Prices: $75.00
• Sizes: 100 mg
• Function Type: Inhibitor
• Cas Number: 2156-56-1
• Chemical Name: Sodiumdichloroacetate
• Formula: C2HCl2NaO2
• Molecular Weight: 150.92
• Description: Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K V 1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo .

Product References

Evidence for existence of tissue-specific regulation of the mammalian pyruvate - Evidence for existence of tissue-specific regulation of the mammalian pyruvate

Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM. Biochem J. 1998 Jan 1;329 ( Pt 1):191-6.

A mitochondria-K+ channel axis is suppressed in cancer and its normalization - A mitochondria-K+ channel axis is suppressed in cancer and its normalization

Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED. Cancer Cell. 2007 Jan;11(1):37-51.