2,3-DCPE hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0975
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Cas Number: 1009555-55-8
• Chemical Name: 2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanolhydrochloride
• Formula: C11H15Cl2NO2.HCl
• Molecular Weight: 300.61
• Purity: >99 %
• Description: Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro . IC 50 values are 0.89 and 12.6 μ M for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.

Product References

Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel - Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel

Wu S, Zhu H, Gu J, Zhang L, Teraishi F, Davis JJ, Jacob DA, Fang B. Cancer Res. 2004 Feb 1;64(3):1110-3.

Induction of S-phase arrest and p21 overexpression by a small molecule - Induction of S-phase arrest and p21 overexpression by a small molecule

Zhu H, Zhang L, Wu S, Teraishi F, Davis JJ, Jacob D, Fang B. Oncogene. 2004 Jun 24;23(29):4984-92.