( S )-3,4-DCPG

• Supplier: Tocris Bioscience
• Catalog: 1394
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 201730-11-2
• Chemical Name: (S)-3,4-Dicarboxyphenylglycine
• Formula: C10H9NO6
• Molecular Weight: 239.18
• Purity: >98 %
• Description: Potent, selective mGlu 8a agonist (EC 50 = 31 nM). Displays > 100-fold selectivity over mGlu 1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo . Also potent anticonvulsant in mice in vivo . Caged ( S )-3,4-DCPG (Cat. No. 3330), ( RS )-3,4-DCPG (Cat. No. 1394) and ( R )-3,4-DCPG (Cat. No. 1395) also available.

Product References

Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations - Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations

Thomas NK, Clayton P, Jane DE. Eur J Pharmacol. 1997 Nov 5;338(2):111-6.

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. - Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.

Moldrich RX, Beart PM, Jane DE, Chapman AG, Meldrum BS. Neuropharmacology. 2001 Apr;40(5):732-5.

(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates - (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates

Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE. Neuropharmacology. 2001 Mar;40(3):311-8.

Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces - Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces

Linden AM, Bergeron M, Baez M, Schoepp DD. Neuropharmacology. 2003 Sep;45(4):473-83.