DCPIB

Name DCPIB
Supplier Tocris Bioscience
Catalog 1302
Prices $139.00, $585.00
Sizes 10 mg, 50 mg
Function Type Blocker
Cas Number 82749-70-0
Chemical Name 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoicacid
Formula C22H28Cl2O4
Molecular Weight 427.37
Purity >98 %
Description Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro .
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Product References

Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with - Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with

Bourke RS, Waldman JB, Kimelberg HK, Barron KD, San Filippo BD, Popp AJ, Nelson LR. J Neurosurg. 1981 Sep;55(3):364-70.

DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced - DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced

Decher N, Lang HJ, Nilius B, Bruggemann A, Busch AE, Steinmeyer K. Br J Pharmacol. 2001 Dec;134(7):1467-79.

Inhibition of glucose-induced electrical activity in rat pancreatic beta-cells by - Inhibition of glucose-induced electrical activity in rat pancreatic beta-cells by

Best L, Yates AP, Decher N, Steinmeyer K, Nilius B. Eur J Pharmacol. 2004 Apr 5;489(1-2):13-9.