DDR1-IN-1 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1540
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamidedihydrochloride
• Formula: C30H31F3N4O3.2HCl
• Molecular Weight: 625.51
• Purity: >98 %
• Description: Selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC 50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

Product References

Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. - Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

Kim HG, Tan L, Weisberg EL, Liu F, Canning P, Choi HG, Ezell SA, Wu H, Zhao Z, Wang J, Mandinova A, Griffin JD, Bullock AN, Liu Q, Lee SW, Gray NS. ACS Chem Biol. 2013 Oct 18;8(10):2145-50.

Structural mechanisms determining inhibition of the collagen receptor DDR1 by - Structural mechanisms determining inhibition of the collagen receptor DDR1 by

Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN. J Mol Biol. 2014 Jun 26;426(13):2457-70.