3-Deazaneplanocin A hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4488
• Prices: $165.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 120964-45-6
• Chemical Name: (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diolhydrochloride
• Formula: C12H14N4O3.HCl
• Molecular Weight: 298.73
• Purity: >98 %
• Description: Histone methyltransferase inhibitor; decreases global histone methylation. Inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro . Induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

Product References

Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine - Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine

Tseng CK, Marquez VE, Fuller RW, Goldstein BM, Haines DR, McPherson H, Parsons JL, Shannon WM, Arnett G, Hollingshead M, et al.. J Med Chem. 1989 Jul;32(7):1442-6.

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene - Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene

Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, Karuturi RK, Tan PB, Liu ET, Yu Q. Genes Dev. 2007 May 1;21(9):1050-63. Epub 2007 Apr 16.

DZNep is a global histone methylation inhibitor that reactivates developmental - DZNep is a global histone methylation inhibitor that reactivates developmental

Miranda TB, Cortez CC, Yoo CB, Liang G, Abe M, Kelly TK, Marquez VE, Jones PA. Mol Cancer Ther. 2009 Jun;8(6):1579-88.

Pluripotent stem cells induced from mouse somatic cells by small-molecule - Pluripotent stem cells induced from mouse somatic cells by small-molecule

Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. Science. 2013 Aug 9;341(6146):651-4.