| Name | 10-DEBC hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4703 |
| Prices | $129.00, $535.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 925681-41-0 |
| Chemical Name | 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazinehydrochloride |
| Formula | C20H25N2OCl.HCl |
| Molecular Weight | 381.34 |
| Purity | >99 % |
| Description | Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells. |
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