Decanoyl-RVKR-CMK

Name Decanoyl-RVKR-CMK
Supplier Tocris Bioscience
Catalog 0477
Prices $165.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 150113-99-8
Formula C34H66ClN11O5
Molecular Weight 744.42
Description Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
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Product References

Inhibition of convertase-related processing of proendothelin-1. - Inhibition of convertase-related processing of proendothelin-1.

Denault JB, D'Orleans-Juste P, Masaki T, Leduc R. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S47-50.

A prohormone convertase cleavage site within a predicted alpha-helix mediates - A prohormone convertase cleavage site within a predicted alpha-helix mediates

Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL, Salton SR. J Biol Chem. 2005 Dec 16;280(50):41595-608. Epub 2005 Oct 12.

Comparative study of the binding pockets of mammalian proprotein convertases and - Comparative study of the binding pockets of mammalian proprotein convertases and

Tian S, Jianhua W. Int J Biol Sci. 2010 Feb 3;6(1):89-95.