Decitabine

Name Decitabine
Supplier Tocris Bioscience
Catalog 3501
Prices $139.00, $579.00
Sizes 10 mg, 50 mg
Cas Number 2353-33-5
Chemical Name 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Formula C8H12N4O4
Molecular Weight 228.21
Purity >99 %
Description Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.
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Product References

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of - Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of

Bender CM, Pao MM, Jones PA. Cancer Res. 1998 Jan 1;58(1):95-101.

Pharmacology of 5-Aza-2'-deoxycytidine (decitabine). - Pharmacology of 5-Aza-2'-deoxycytidine (decitabine).

Momparler RL. Semin Hematol. 2005 Jul;42(3 Suppl 2):S9-16.