Deltarasin

• Supplier: Tocris Bioscience
• Catalog: 4149
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 1440898-82-7
• Chemical Name: 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazoletrihydrochloride
• Formula: C40H37N5O.3HCl
• Molecular Weight: 713.14
• Purity: >99 %
• Description: High affinity PDE δ -KRAS interaction inhibitor (K d = 41 nM); binds to PDE δ . Reduces proliferation and induces cell death of KRAS-dependent Panc-Tu-1 and Capan-1 pancreatic cancer cells. Attenuates tumor growth of Panc-Tu-1 xenografts in mice.

Product References

Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS - Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H. Nature. 2013 May 30;497(7451):638-42.

Structure guided design and kinetic analysis of highly potent benzimidazole - Structure guided design and kinetic analysis of highly potent benzimidazole

Zimmermann G, Schultz-Fademrecht C, Kuchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H. J Med Chem. 2014 Jun 26;57(12):5435-48.