2-Deoxy- D -glucose

Name 2-Deoxy- D -glucose
Supplier Tocris Bioscience
Catalog 1819
Prices $49.00
Sizes 50 mg
Cas Number 154-17-6
Chemical Name 2-Deoxy-D-arabino-hexose
Formula C6H12O5
Molecular Weight 164.16
Description Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).
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Product References

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in - Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in

Maher JC, Krishan A, Lampidis TJ. Cancer Chemother Pharmacol. 2004 Feb;53(2):116-22. Epub 2003 Nov 7.

2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low - 2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low

Kang HT, Hwang ES. Life Sci. 2006 Feb 16;78(12):1392-9. Epub 2005 Aug 18.