Deoxynivalenol

Name Deoxynivalenol
Supplier Tocris Bioscience
Catalog 1259
Prices $95.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 51481-10-8
Chemical Name 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
Formula C15H20O6
Molecular Weight 296.32
Description Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF- κ B into the nucleus.
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Product References

Deoxynivalenol induces p38 interaction with the ribosome in monocytes and - Deoxynivalenol induces p38 interaction with the ribosome in monocytes and

Bae HK, Pestka JJ. Toxicol Sci. 2008 Sep;105(1):59-66.

Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced - Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced

Shi Y, Porter K, Parameswaran N, Bae HK, Pestka JJ. Toxicol Sci. 2009 Jun;109(2):247-55.

Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and - Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and

Krishnaswamy R, Devaraj SN, Padma VV. Free Radic Biol Med. 2010 Jul 1;49(1):50-60. doi: