Dexrazoxane hydrochloride

Name Dexrazoxane hydrochloride
Supplier Tocris Bioscience
Catalog 2749
Prices $129.00, $535.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1263283-43-7
Chemical Name 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride
Formula C11H16N4O4.HCl
Molecular Weight 304.73
Purity >98 %
Description Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
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Product References

Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects - Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects

Lebrecht D, Geist A, Ketelsen UP, Haberstroh J, Setzer B, Walker UA. Br J Pharmacol. 2007 Jul;151(6):771-8. Epub 2007 May 21.

Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in - Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in

Spallarossa P, Altieri P, Pronzato P, Aloi C, Ghigliotti G, Barsotti A, Brunelli C. J Pharmacol Exp Ther. 2010 Jan;332(1):87-96.