DFB

• Supplier: Tocris Bioscience
• Catalog: 3071
• Prices: $95.00, $399.00
• Sizes: 10 mg, 50 mg
• Cas Number: 15332-10-2
• Chemical Name: [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde
• Formula: C14H10F2N2
• Molecular Weight: 244.24
• Purity: >99 %
• Description: Novel allosteric potentiator of the metabotropic glutamate receptor mGlu 5 . Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu 5 without any effect at other mGlu subtypes (EC 50 for potentiation = 2 - 5.3 μ M).

Product References

A family of highly selective allosteric modulators of the metabotropic glutamate - A family of highly selective allosteric modulators of the metabotropic glutamate

O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Lindsley CW, Schaffhauser HJ, Sur C, Pettibone DJ, Conn PJ, Williams DL Jr. Mol Pharmacol. 2003 Sep;64(3):731-40.

Allosteric potentiators of metabotropic glutamate receptor subtype 5 have - Allosteric potentiators of metabotropic glutamate receptor subtype 5 have

Zhang Y, Rodriguez AL, Conn PJ. J Pharmacol Exp Ther. 2005 Dec;315(3):1212-9. Epub 2005 Aug 31.