DG 172 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2761
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1361504-77-9
• Chemical Name: (αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitriledihydrochloride
• Formula: C20H20BrN3.2HCl
• Molecular Weight: 455.22
• Purity: >98 %
• Description: Potent PPAR β / δ inverse agonist (IC 50 = 26.9 nM). Inhibits Angptl4 gene expression in mouse myoblasts (IC 50 = 9.5 nM) in vitro . Also augments GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells in culture. Orally available.

Product References

(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile - (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile

Lieber S, Scheer F, Meissner W, Naruhn S, Adhikary T, Muller-Brusselbach S, Diederich WE, Muller R. J Med Chem. 2012 Mar 22;55(6):2858-68.

The inverse agonist DG172 triggers a PPARbeta/delta-independent myeloid lineage - The inverse agonist DG172 triggers a PPARbeta/delta-independent myeloid lineage

Lieber S, Scheer F, Finkernagel F, Meissner W, Giehl G, Brendel C, Diederich WE, Muller-Brusselbach S, Muller R. Mol Pharmacol. 2015 Feb;87(2):162-73.