2,4-Diamino-6-hydroxypyrimidine

Name 2,4-Diamino-6-hydroxypyrimidine
Supplier Tocris Bioscience
Catalog 0805
Prices $95.00
Sizes 50 mg
Function Type Inhibitor
Cas Number 56-06-4
Formula C4H6N4O
Molecular Weight 126.12
Purity >99 %
Description GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).
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Product References

Pteridine biosynthesis in human endothelial cells. Impact on nitric - Pteridine biosynthesis in human endothelial cells. Impact on nitric

Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G, Schmidt K, Weiss G, Wachter H. J Biol Chem. 1993 Jan 25;268(3):1842-6.

Selective inhibitors of neuronal nitric oxide synthase--is no NOS really good NOS - Selective inhibitors of neuronal nitric oxide synthase--is no NOS really good NOS

Moore PK, Handy RL. Trends Pharmacol Sci. 1997 Jun;18(6):204-11.

GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, - GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,

Xie L, Smith JA, Gross SS. J Biol Chem. 1998 Aug 14;273(33):21091-8.