Diclofenac sodium salt

• Supplier: Tocris Bioscience
• Catalog: 3698
• Prices: $49.00
• Sizes: 50 mg
• Cas Number: 15307-79-6
• Chemical Name: 2-[(2,6-Dichlorophenyl)amino]benzeneaceticacidsodiumsalt
• Formula: C14H10Cl2NNaO2
• Molecular Weight: 318.13
• Purity: >99 %
• Description: Nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC 50 values are 0.075 μ M for COX-1 and 0.038 μ M for COX-2 in human whole blood assay).

Product References

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 - Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2

Laneuville O, Breuer DK, Dewitt DL, Hla T, Funk CD, Smith WL. J Pharmacol Exp Ther. 1994 Nov;271(2):927-34.

Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. - Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity.

Bort R, Ponsoda X, Jover R, Gomez-Lechon MJ, Castell JV. J Pharmacol Exp Ther. 1999 Jan;288(1):65-72.

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 - Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2

Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7563-8.