DIDS

• Supplier: Tocris Bioscience
• Catalog: 5034
• Prices: $59.00
• Sizes: 50 mg
• Function Type: Blocker
• Cas Number: 67483-13-0
• Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonicaciddisodiumsalt
• Formula: C16H8N2Na2O6S4
• Molecular Weight: 498.48
• Purity: >95 %
• Description: ClC-Ka chloride channel blocker (IC 50 = 100 μ M). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC 50 = 4.88 μ M in rat DRG neurons). Inhibits RAD51 recombinase activity (K D = 2 μ M).

Product References

Regulation of human placental chloride channel by arachidonic acid and other cis - Regulation of human placental chloride channel by arachidonic acid and other cis

Riquelme G, Parra M. Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):469-75.

New light on the "old" chloride channel blocker DIDS. - New light on the "old" chloride channel blocker DIDS.

Wulff H. ACS Chem Biol. 2008 Jul 18;3(7):399-401.

DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and - DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and

Ishida T, Takizawa Y, Kainuma T, Inoue J, Mikawa T, Shibata T, Suzuki H, Tashiro S, Kurumizaka H. Nucleic Acids Res. 2009 Jun;37(10):3367-76.

Agonist-dependent potentiation of vanilloid receptor transient receptor potential - Agonist-dependent potentiation of vanilloid receptor transient receptor potential

Zhang X, Du XN, Zhang GH, Jia ZF, Chen XJ, Huang DY, Liu BY, Zhang HL. Mol Pharmacol. 2012 May;81(5):689-700.