Dihydrexidine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4583
• Prices: $139.00, $585.00
• Sizes: 5 mg, 25 mg
• Function Type: Agonist
• Cas Number: 158704-02-0
• Chemical Name: (±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridinehydrochloride
• Formula: C17H17NO2.HCl
• Molecular Weight: 303.79
• Purity: >98 %
• Description: A potent, full efficacy dopamine D 1 agonist which shows no agonist activity at peripheral D 2 receptors or adrenoceptors at doses which cause maximal stimulation of D 1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo .

Product References

Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. - Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist.

Lovenberg TW, Brewster WK, Mottola DM, Lee RC, Riggs RM, Nichols DE, Lewis MH, Mailman RB. Eur J Pharmacol. 1989 Jul 4;166(1):111-3.

trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly - trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly

Brewster WK, Nichols DE, Riggs RM, Mottola DM, Lovenberg TW, Lewis MH, Mailman RB. J Med Chem. 1990 Jun;33(6):1756-64.

Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in - Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in

Taylor JR, Lawrence MS, Redmond DE Jr, Elsworth JD, Roth RH, Nichols DE, Mailman RB. Eur J Pharmacol. 1991 Jul 9;199(3):389-91.

Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist. - Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist.

Kohli JD, Horn PT, Glock D, Brewster WK, Nichols DE. Eur J Pharmacol. 1993 Apr 22;235(1):31-5.