Dihydroergotoxine mesylate

Name Dihydroergotoxine mesylate
Supplier Tocris Bioscience
Catalog 0475
Prices $105.00
Sizes 100 mg
Cas Number 8067-24-1
Description A complex of closely related alkaloid salts. Binds with high affinity to the GABA A receptor Cl - channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic ( α 1 ) receptors. Displays antiproliferative activity in vitro (IC 50 = 18 - 38 μ M in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo . Orally active.
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Product References

Dihydrogenated ergot compounds bind with high affinity to GABAA - Dihydrogenated ergot compounds bind with high affinity to GABAA

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Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in - Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in

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Abdul M, Mccray SD, Hoosein NM. Acta Oncol. 2008;47(8):1546-50.