Dihydrokainic acid

• Supplier: Tocris Bioscience
• Catalog: 0505
• Prices: $79.00, $169.00, $705.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 52497-36-6
• Chemical Name: (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineaceticacid
• Formula: C10H17NO4
• Molecular Weight: 215.25
• Description: EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake (K i = 23 μ M). 130-fold selective over EAAT1 and EAAT3 (K i > 3 mM). Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ .

Product References

Effects of dihydrokainic acid on extracellular amino acids and neuronal - Effects of dihydrokainic acid on extracellular amino acids and neuronal

Munoz MD, Herreras O, Herranz AS, Solis JM, Martin del Rio R, Lerma J. Neuropharmacology. 1987 Jan;26(1):1-8.

Functional comparisons of three glutamate transporter subtypes cloned from human - Functional comparisons of three glutamate transporter subtypes cloned from human

Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG. J Neurosci. 1994 Sep;14(9):5559-69.

The neuronal and epithelial human high affinity glutamate transporter. Insights - The neuronal and epithelial human high affinity glutamate transporter. Insights

Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP, Hediger MA. J Biol Chem. 1994 Aug 12;269(32):20599-606.