7,8-Dihydroxyflavone

• Supplier: Tocris Bioscience
• Catalog: 0749
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 38183-03-8
• Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
• Formula: C15H10O4
• Molecular Weight: 254.24
• Purity: >98 %
• Description: Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (K d = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo . Exhibits neuroprotective effects in an HD mouse model.

Product References

7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory - 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory

Andero R, Daviu N, Escorihuela RM, Nadal R, Armario A. Hippocampus. 2012 Mar;22(3):399-408.

Small-molecule TrkB receptor agonists improve motor function and extend survival - Small-molecule TrkB receptor agonists improve motor function and extend survival

Jiang M, Peng Q, Liu X, Jin J, Hou Z, Zhang J, Mori S, Ross CA, Ye K, Duan W. Hum Mol Genet. 2013 Jun 15;22(12):2462-70.