DIM

Name DIM
Supplier Tocris Bioscience
Catalog 0685
Prices $49.00
Sizes 50 mg
Function Type Activator
Cas Number 1968-05-4
Chemical Name 3,3'-Methylenediindole
Formula C17H14N2
Molecular Weight 246.31
Purity >99 %
Description Activator of Chk2 that causes G 2 /M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
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Product References

Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for - Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for

Kandala PK, Srivastava SK. Mol Pharmacol. 2010 Aug;78(2):297-309.

Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane - Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane

Kandala PK, Wright SE, Srivastava SK. J Pharmacol Exp Ther. 2012 Apr;341(1):24-32.

3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell - 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell

Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH, Benninghoff AD. PLoS One. 2012;7(4):e34975.