( S )-(+)-Dimethindene maleate

Name ( S )-(+)-Dimethindene maleate
Supplier Tocris Bioscience
Catalog 3201
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 136152-65-3
Chemical Name N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanaminemaleate
Formula C20H24N2.C4H4O4
Molecular Weight 408.5
Purity >99 %
Description Enantiomer that is a subtype-selective M 2 muscarinic receptor antagonist (pK i values are 7.08, 7.78, 6.70 and 7.00 for M 1 , M 2 , M 3 and M 4 receptors respectively). Also H 1 histamine receptor antagonist (pK i = 7.48).
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Product References

The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor - The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor

Pfaff O, Hildebrandt C, Waelbroeck M, Hou X, Moser U, Mutschler E, Lambrecht G. Eur J Pharmacol. 1995 Nov 24;286(3):229-40.

Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and - Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and

Lambrecht G, Gross J, Mutschler E. Life Sci. 1999;64(6-7):403-10.