Dimethylenastron

• Supplier: Tocris Bioscience
• Catalog: 1425
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 863774-58-7
• Chemical Name: 2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
• Formula: C16H18N2O2S
• Molecular Weight: 302.39
• Purity: >99 %
• Description: Inhibitor of mitotic motor kinesin Eg5 (IC 50 = 200 nM). Arrests mitosis, triggers apoptosis and up-regulates Hsp-70 expression in multiple human myeloma cell lines. Also inhibits the growth of several types of cancer cell lines (EC 50 values are 330, 603, 743 and 881 nM in HCT116, Htert-HME1, BxPC3, K562 and NCI-H1299 cancer cells, respectively). Suppresses the migration and invasion of PANC1 cells in vitro . Cytoprotective.

Product References

Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the - Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the

Liu M, Aneja R, Liu C, Sun L, Gao J, Wang H, Dong JT, Sarli V, Giannis A, Joshi HC, Zhou J. J Biol Chem. 2006 Jun 30;281(26):18090-7. Epub 2006 Apr 20.

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity - Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity

Kaan HY, Ulaganathan V, Rath O, Prokopcova H, Dallinger D, Kappe CO, Kozielski F. J Med Chem. 2010 Aug 12;53(15):5676-83.

Dimethylenastron suppresses human pancreatic cancer cell migration and invasion - Dimethylenastron suppresses human pancreatic cancer cell migration and invasion

Sun XD, Shi XJ, Sun XO, Luo YG, Wu XJ, Yao CF, Yu HY, Li DW, Liu M, Zhou J. Acta Pharmacol Sin. 2011 Dec;32(12):1543-8.